摘要 :
<abstract_text><p>Flavonoids are a large group of polyphenolic compounds that are present in almost all higher plants. Recent research demonstrated a wide range of biological effects of these compounds under both normal and variou...
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<abstract_text><p>Flavonoids are a large group of polyphenolic compounds that are present in almost all higher plants. Recent research demonstrated a wide range of biological effects of these compounds under both normal and various pathological conditions. Apparently, the biological activity of most flavonoids is due mainly to their ability to penetrate into cells and block enzymes of signaling pathways and transcription factors, including those involved in the activation, proliferation, and realization of effector functions of immune system cells. Moreover, it should be noted that flavonoids were highly efficacious in several instances in experimental therapy of model immune pathologies, suggesting that they were promising as platforms for creating new pharmacological agents that suppress or "normalize" the immune response.</p></abstract_text>
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摘要 :
We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by t...
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We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.
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摘要 :
An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 ...
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An experimental study revealed the effect on modified bioflavonoid on the inhibition of secretion of IFN-gamma and IL-2 by ConA-stimulated mononuclear cells. These changes were accompanied by an increase in the secretion of IL-17 and IL-6. Our results suggest the differentiation of CD4(+) T helper cells into Th1 and Th17 subpopulations. The reference drug quercetin dihydrate induced an insignificant change in the level of IL-2 and IL-6 and small increase in IFN-gamma content. The content of IL-17 was shown to decrease above the detection limit.
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